8). Figure 1: A sequence alignment of amino-acid residues near the H-9 (α9) and H-10 (α10) helix of class C β-lactamases with extended substrate spectrum.

This project will develop state of the art wearable sensors to measure antimicrobial resistance, which is key to prevent antibiotic misuse.

† VIMs are made up of 266 amino acid residues with the exception of VIM-7 (265 residues) and VIM-18 (262 residues). VIM-21, -22 and -27 have been assigned in the Lahey Clinic [201], but there ...

The inhibitor prevents bacterial enzymes such as metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs) from breaking down the antibiotic before it has its desired effect to treat the infection.