In RTX-003, a CD25 T reg cell-targeting program, RubrYc used MEMs to identify epitopes and antibodies that enhance antibody directed cellular cytotoxicity (ADCC). This results in T reg cell ...

Figure 1: Antibody design to improve homogeneity and ... and associated with enhanced or silenced effector functions (ADCC or complement-dependent cytotoxicity) are being investigated in clinical ...

Source: Sino Biological Inc. To mediate antibody-dependent cellular cytotoxicity (ADCC), NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA). A new area of cancer immunotherapy is ...

Data were summarized with the search of 'colorectal' and 'antibody' as of August 2012 at ClinicalTrials.gov [202]. EGFR: EGF receptor; mAb: Monoclonal antibody; VEGFR: VEGF receptor. The authors ...

or bring a T cell adjacent to the tumor (e.g., bispecific mAb). ADCC: Antibody-dependent cellular cytotoxicity; mAb: Monoclonal antibody.

MCLA-145 is under clinical development by Merus and currently in Phase I for Head And Neck Squamous Cell Carcinoma (HNSC).

CHENGDU, China I January 07, 2025 I The board (the “Board”) of directors (“Directors”) of Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (the “Company”) is ...

and antibody dependent cellular phagocytosis (ADCP). Hyaluronidase increases permeability of the subcutaneous tissue by depolymerizing hyaluronan, a polysaccharide found in the extracellular matrix.

SYN-2510/IMM2510 is differentiated from other PD-(L)1xVEGF bispecific antibodies by its VEGF trap, which binds multiple VEGF receptor ligands beyond VEGF-A, a bispecific structure which leverages ...