The APC gene was discovered by Kimmel Cancer Center researchers in 1991, and mutations in APC occur in over 90% of all colorectal tumors. "HMGA1 functions like a molecular 'key' that 'opens ...

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"The gene-specific classification criteria we developed have now allowed us to reclassify a significant proportion of VUS of the APC gene into a medically relevant category," says Prof. Aretz ...