Renal hypoperfusion occurs as a result of reduced cardiac output, resulting in the activation of the renin–angiotensin–aldosterone system, which compensates for the hypoperfusion. However ...

The investigational aldosterone synthase inhibitor lorundrostat effectively lowered 24-hour BP for adults with well-treated, ...

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This suggests that a preexistent partial hormonal resistance in young infants might aggravate the impaired renal aldosterone sensitivity secondary to urinary infections. This putative aldosterone ...

Lorundrostat is an orally-administered highly selective aldosterone synthase inhibitor that reduces aldosterone levels by inhibiting CYP11B2. The Launch-HTN trial (ClinicalTrials.gov Identifier ...

In March 2025, Shandong Suncadia Medicine Co., Ltd. conducted a phase II Clinical Study of Efficacy and Safety of HRS-1780 ...

By competing with aldosterone for receptor sites in distal renal tubules, spironolactone increases sodium chloride and water excretion while conserving potassium and hydrogen ions. The inhibition ...

Elevated aldosterone stimulates sodium reabsorption ... This specific protein facilitates the reabsorption of magnesium in the kidney tubules, resulting in low magnesium in the blood.

Aldosterone antagonists (spironolactone ... New York Heart Association functional class IV symptoms, preserved renal function and a normal potassium concentration. Spironolactone was investigated ...

It suppresses the renin-angiotensin-aldosterone system ... Postsympathectomy. Renal or hepatic impairment. Dialysis (esp. high-flux membrane). Gout. Asthma. SLE. Acute myopia.