The human kidney displays a tubular immaturity at birth, with sodium waste, responsible for a negative sodium balance, and an impaired ability to reabsorb water (1), which is aggravated under ...

...physicians must be aware of clinical circumstances that may promote the development of hyperkalemia The renin–angiotensin–aldosterone system (RAAS) has a pathogenetic role in several ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

The investigational aldosterone synthase inhibitor lorundrostat effectively lowered 24-hour BP for adults with well-treated, ...

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In March 2025, Shandong Suncadia Medicine Co., Ltd. conducted a phase II Clinical Study of Efficacy and Safety of HRS-1780 ...

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally, when ...

Over time, the retention of sodium leads to crackles, peripheral edema, hepatomegaly with ascites, increased blood volume, and increased cardiac filling pressures. Although diuretics do not ...

Lisinopril, hydrochlorothiazide; 10mg/12.5mg, 20mg/12.5mg, 20mg/25mg; tabs. Lisinopril inhibits angiotensin-converting enzyme. It suppresses the renin-angiotensin-aldosterone system. The mechanism ...