Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

Diabetes affects millions worldwide, often triggering complications such as insulin resistance and fatty liver disease. To ...

Previous research has shown that mammals accumulate LCA during calorie restriction and it activates a key molecule involved in metabolism called AMP-activated protein kinase, or AMPK. AMPK ...

This milestone, achieved in collaboration with Eli Lilly and Company (Lilly), targets a specific isoform of AMP-activated protein kinase (AMPK) for the treatment of cardiometabolic diseases.