In AD, a small peptide, amyloid β-protein (Aβ), forms long, insoluble amyloid fibrils, which accumulate in spherical microscopic deposits known as senile plaques. However, the relevance of these ...

Previous work had investigated amyloid formation in the presence of polymeric nanoparticles 5. The fibrillization kinetics were affected by the peptide examined, the surface chemistry of the ...

(b) in hippocampus. (c-e) Plaque load in nontransgenic and PD-hAPP mice treated with soluble RAGE (+sRAGE). -sRAGE, untreated mice. (f) Image analysis of amyloid load from c-e. (g) Serum from ...

1 Frank P. Smith Laboratories for Neurosurgery, Department of Neurosurgery and Division of Neurovascular Biology, Center for Aging and Developmental Biology, University of Rochester Medical Center ...

“Structure Dependent Inhibition of b-Fibrillogenesis by Melatonin,” M. Pappolla, P. Bozner, C. Soto, M. Zagorski, H. Shao, N. K. Robakis, B. Frangione, and J ...

The all-out assault to impede production of b-amyloid (Ab), the plaque-forming peptide believed by many to cause neurodegenerative Alzheimer's disease (AD), entails a war on two fronts. For those ...

The study, titled "Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal ... step towards unraveling the mysteries of the b-amyloid-like environment which can be found in AD and ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

It belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists ... carry genetic mutations that cause the buildup of amyloid plaques and tau tangles, the two main hallmarks ...