Study suggests stalled amyloid protein production drives Alzheimer's disease
Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. The research, ...
Researchers illuminate new structures of a critical amyloid protein
The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...
ALZFORUM13d
Lactylation—a New Protein Modification That Slows Alzheimer’s?
Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...
COVID-19 linked to increase in biomarkers for abnormal brain proteins
Researchers have uncovered a link between COVID-19 and blood markers linked to faulty proteins in the brain. The analysis, ...
Nature22d
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
Several mutations affecting β-amyloid, either to APP 1,2,3 or to presenilins 4,5, are capable of producing familial forms of AD 6,7,8,9,10,11,12. APP 695 SWE mice expressing transgenic human APP ...
Alzheimer's Scientists Reveal New Early Warning Sign
Taking too long to enter the phase of sleep in which we dream may be an early sign of Alzheimer's disease. This is the ...
UC San Francisco2d
Delayed REM sleep could be an early sign of Alzheimer’s
Taking longer to enter the dream phase can disrupt the ability to consolidate memories and interfere with emotion regulation.
ALZFORUM8d
Another γ-Secretase Binding Partner Implicated in Aβ Production
EBP1 is low in Alzheimer’s disease brains, hinting at human relevance. “Our study suggests that … preservation of functional EBP1 could be a therapeutic strategy for AD,” the authors noted. The ...