Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.

Several mutations affecting β-amyloid, either to APP 1,2,3 or to presenilins 4,5, are capable of producing familial forms of AD 6,7,8,9,10,11,12. APP 695 SWE mice expressing transgenic human APP ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

They also say that their graphene grid method could be used to determine the structures of other small and unstable proteins—including the amyloid-beta peptide that builds up in the brain in ...

Progress in deciphering the fundamental biological mechanism of Alzheimer's disease (AD) is proceeding at an impressive pace. A consensus has emerged among many investigators that cerebral ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

Taking too long to enter the phase of sleep in which we dream may be an early sign of Alzheimer's disease. This is the ...

Immunohistochemical analyses using specific antibodies were used to confirm the presence of beta-secretase and amyloid precursor proteins in oligodendrocytes in mice. Post-mortem tissue from ...

Scientists have discovered a molecular timer in mice – activated early in pregnancy – that controls when they give birth to ...

Other signs of Alzheimer’s, such as brain shrinkage and tangles of a second abnormal protein called tau, are thought to come later. The amyloid cascade hypothesis remains the most influential ...