generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques ...

Ever since Alois Alzheimer first described the neurological changes that characterize the disease that now bears his name, amyloid plaques ... s targeting of Aβ oligomers, has opened the ...

The beta amyloid peptide (Abeta) is the primary component of the senile plaques observed ... We propose that a primary mechanism of Abeta toxicity is the formation of membrane-damaging oligomers, ...

Amyloid-beta is a protein fragment naturally produced ... Alzheimer’s begins when Aβ42 molecules stick together to form clumps called oligomers. These oligomers aggregate into amyloid plaques ...

PMN310, a humanized IgG1 antibody, is engineered to selectively target toxic oligomers of amyloid-beta (AßO)—which are believed to be a key driver of Alzheimer’s pathology—while avoiding interaction ...

This allows copper and zinc to react with Aβ released into the synaptic cleft to form oxidized, cross-linked soluble oligomers and precipitated amyloid. While the soluble Aβ monomers are ...

With UdeM professor Jonathan Brouillette, Mongrain said she's "looking to identify biomarkers present at the onset of ...

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is ...

Scientists at the Bose Institute in Kolkata, an autonomous institute of the Department of Science and Technology, have shown that Ayurveda can provide new hope for Alzheimer’s disease. The team, led ...

Alzinova AB (publ) (ticker: ALZ) announces that another milestone in the development of the company's vaccine candidate ALZ-101 for Alzheimer's disease has been reached. All study participants have no ...

Alzinova AB (publ) (ticker: ALZ) hereby announces that the Company's CMO is stepping down from her role after mutual agreement. The basis is a strategic decision to appoint a CMO in place at the Compa ...