"These findings are in keeping with our 'stalled complex' hypothesis, where it is these enzyme-substrate complexes that trigger neurodegeneration even in the absence of amyloid beta-protein production ...

where it is these enzyme-substrate complexes that trigger neurodegeneration even in the absence of amyloid beta-protein production." "Difficulties in pinpointing the drivers of Alzheimer's disease ...

where it is these enzyme-substrate complexes that trigger neurodegeneration even in the absence of amyloid beta-protein production.” “Difficulties in pinpointing the drivers of Alzheimer’s ...

Figure 1: Imaging of amyloid-β deposits in the live mouse. Figure 3: In vivo imaging of amyloid-β deposits in 20-month-old homozygous PDAPP mice. Immunostaining with biotinylated or ...

Several mutations affecting β-amyloid, either to APP 1,2,3 or to presenilins 4,5, are capable of producing familial forms of AD 6,7,8,9,10,11,12. APP 695 SWE mice expressing transgenic human APP ...

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the ...

Alzheimer’s disease is a dominant form of dementia, representing 60 to 70 percent of cases. Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky ...

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is ...

Researchers at IISc Bengaluru discover potential drug-free treatment for diabetes by enhancing beta-cell function with small ...

The Washington University trial comes as part of a larger platform study, which hopes to understand whether the disease can ...