Antigen-presenting cells work to present peptides derived from exogenous and endogenous antigens to circulating T cells, sparking off an immune response. Dendritic cells are unique amongst antigen ...

T cells, move over. B cells are now reported, in a recent paper in Nature, to have their own immunological synapses with APCs. Only this time the antigen is whole and B cells don't keep it to ...

An army of defensive cells protects the body against invasion by foreign substances: the antigens. The specialized functions of these various "inflammatory" cells are now being clarified ...

Initially designed for hematological malignancies, CAR-T therapy is now being expanded to target solid tumors using specialized CAR-T cells that attack specific antigens. Ongoing clinical trials are ...

The body stores white blood cells in different places, known as lymphoid organs. An antigen is any substance that can spark an immune response. In many cases, an antigen is a bacterium ...

Research from the University of Colorado Anschutz Medical Campus shows that CAR-T cells—engineered to fight cancer—can retain memories of past antigen encounters, potentially improving ...

Although CAR T-cell therapies have reached significant clinical success in hematological malignancies, their utility in solid tumors remains limited. One of the main challenges is the scarcity of ...

The paper is titled "Neoself-antigens are the primary target for autoreactive T cells in human lupus." Autoimmune diseases develop when the body's immune system mistakenly attacks its own tissues ...

A bold funding initiative aims to help scientists predict a T cell’s target antigens, with implications far beyond cancer ...

The effective transmission of viral particles from cell-to-cell depends heavily on ... in the study of infectious diseases are recombinant antigens. They are frequently employed in the context ...

New research shows how a specially trained population of immune cells keeps the peace by preventing other immune cells from attacking their own. The study provides a better understanding of immune ...