The pharmacotherapy of schizophrenia is currently dominated by atypical antipsychotics ... modulate muscarinic receptors by targeting the acetylcholine binding site have been largely unsuccessful ...

Newer antipsychotics, such as clozapine, olanzapine, risperidone, quetiapine and ziprasidone, have a different receptor-binding profile, interacting with both D and 5-HT receptors; they less ...