GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown of purine nucleotides in cells. Disorders of purine metabolism can lead to ...

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP)-;the ...

Adenylosuccinate lyase deficiency (ADSLD) is a rare genetic disorder that affects purine metabolism, leading to various neurodevelopmental issues. Purines are essential building blocks for DNA and ...