they transitioned the astrocytes to a pathogenic state by adding microglia-derived cytokines, which are the molecular cues that induce reactivity in neurodegenerative diseases. 2 Using this system to ...

Microglia phagocytose astrocyte end feet which is one of the components of BBB. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert!

We use induced pluripotent stem cells (iPSCs) representing neurological and psychiatric diseases. Differentiation of iPSCs into neurons, astrocytes, microglia allow us to analyze aberrant gene and ...

Astrocytes are notoriously two-faced—calmly coddling neurons one minute, then ruthlessly consuming their synapses the next. Why these dramatic mood swings? Blame the EphA4 receptor, according to a ...

Tyrosine kinase 2 (TYK2), expressed in astrocytes and microglia, is involved in the activation of pathways triggered by proinflammatory cytokines, such as IL-23, IL-12 and type I interferons (IFNs), ...

They spotted many of the genes they suspected of responding to lecanemab expressed in microglia huddled around plaques. There were far more abundant in the lecanemab-treated case than in controls.

Differentiation of iPSCs into neurons, astrocytes and microglia allow us to analyze aberrant gene and protein expression, function and metabolism in developing and maturing human brain well before the ...

Astrocytes are star-shaped glial cells in ... "With our colleagues at AbbVie Inc, we also studied progression of microglia, endothelial, and neuronal cells in AD," added Das.

S cientists have discovered that a specific type of brain cell, called an astrocyte, may be a key player in how cannabis influences the developing brain. Their new research in mice, published in ...