Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

Mitochondria and mitochondrial autophagy play a vital role in cellular health and failure of these pathways can have a devastating effect on cellular homeostasis.

A Dundee academic has been awarded a prestigious national prize for his work on neurodegenerative diseases, including ...

The ssRNA viruses have been known to exploit endosomal vesicular trafficking's pathways associated with autophagy signaling. The non-structural proteins are the key players to interfere with these ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

In this study, the researchers revealed that autophagy pathway in astrocytes (non-neuronal cells in the brain) removes amyloid-beta (Aβ) oligomers, the toxic proteins found in the brains of AD ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

Researchers uncover how aging disrupts autophagy, driving neurodegeneration, and explore therapeutic pathways to restore ...

Researchers have found cold-water acclimation affects cellular function, upregulating protective mechanisms that could ...