Depression is one of the most common and disabling mental health conditions in the world, affecting over 10% of people ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel ...

Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

Mitochondria and mitochondrial autophagy play a vital role in cellular health and failure of these pathways can have a devastating effect on cellular homeostasis.

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Originally characterised as a hormonal and starvation response, it is now well established that autophagy has a much broader role in biology, including organelle remodeling, protein quality control, ...

Researchers at Zhejiang University found that acute stress increases natural repair mechanisms in the brain, while chronic ...

Daniela Hernandez extends her health and science reporting to cover a variety of relevant subjects from Covid-19 to climate change.

However, our understanding of the mechanisms by which cells utilize the autophagy pathway to promote both normal development and cancer progression is limited. To help elucidate these mechanisms, the ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...