Scientists performed a first-ever clinical test of the therapy avapritinib in pediatric patients with high-grade glioma. They ...

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, ...

A study, published in Cancer Cell, shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric ...

Avapritinib is an oral inhibitor of KIT and PDGFRA kinases, and is being developed for GIST and systemic mastocytosis (SM), two diseases that are linked to mutations in these enzymes.

High-grade glioma, a difficult-to-treat and aggressive form of pediatric and adult brain cancer, responded to FDA-approved avapritinib. | Drug Discovery And Development ...

A new therapy offers hope for treating pediatric brain tumors, targeting cancer cells while minimizing side effects for young ...

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A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food and Drug ...