文章中说，血小板源性生长因子受体α（PDGFRA）对肿瘤的发生至关重要，在高级别胶质瘤（HGG）中经常发生基因组改变。在包含 261 例儿童高级别胶质瘤的综合数据集中，研究者检测到 15% 的病例存在 PDGFRA 突变和/或扩增，这表明 ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a ...

本文研究发现 Avapritinib 对 PDGFRA 改变的儿童高级别胶质瘤（HGG）有治疗潜力，值得关注。 ### 儿童高级别胶质瘤治疗现状与挑战 儿童高级别胶质瘤（pediatric high-grade gliomas，pHGGs），如 H3K27M 弥漫性中线胶质瘤（diffuse midline gliomas，DMGs），是一类致命的疾病 ...

High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a ...

A study, published in Cancer Cell, shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United ...

Though this work is preliminary, Koschmann is hopeful that avapritinib could be an additional tool to help patients. "We know a single drug is not going to be enough for this disease," he said.

A new therapy offers hope for treating pediatric brain tumors, targeting cancer cells while minimizing side effects for young ...

High-grade glioma, a difficult-to-treat and aggressive form of pediatric and adult brain cancer, responded to FDA-approved avapritinib. | Drug Discovery And Development ...

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