A common gastrointestinal cancer drug that crosses the blood-brain barrier showed promise in patients with aggressive ...

本文研究发现 Avapritinib 对 PDGFRA 改变的儿童高级别胶质瘤（HGG）有治疗潜力，值得关注。 ### 儿童高级别胶质瘤治疗现状与挑战 儿童高级别胶质瘤（pediatric high-grade gliomas，pHGGs），如 H3K27M 弥漫性中线胶质瘤（diffuse midline gliomas，DMGs），是一类致命的疾病 ...

Next, the team tested the activity of four PDGFRA inhibitors (dasatinib, crenolanib, axitinib, and avapritinib) against a panel of glioma cell lines with PDGFRA alterations. Of these drugs ...

More information: Lisa Mayr et al, Effective targeting of PDGFRA-altered high-grade glioma with avapritinib, Cancer Cell (2025). DOI: 10.1016/j.ccell.2025.02.018 Provided by Children's Hospital Boston ...

A study, published in Cancer Cell, shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United ...

Pediatric-type high-grade gliomas are currently incurable brain tumors with median survival times less than 18 months after initial diagnosis. Avapritinib is a small molecule that crosses the ...

Blueprint Medicines has new data for its lead cancer drug avapritinib in gastrointestinal stromal tumours (GIST) that set it on course for regulatory filings – and a close race to market with ...