"Although B cell lineage plasticity has been observed following knockout of several lineage-specific transcription factors," ...

The chimeric fusion oncogene early B-cell factor 1–platelet-derived growth ... EBF1 is a nuclear transcription factor required for normal B-lineage specification, commitment and development.

The firm is also shuttering its allogeneic cell therapy platform and has tasked a new CEO to lead the company through a merger.

They then examined how this affected different cell types, finding that the knockout negatively impacted HSCs and immune ...