This study provides a potentially useful investigation into the positive role of BDNF/TrkB signaling in implanted dental pulp stem cells to enhance dentin regeneration in the context of dental caries.

Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

于是，该研究检测了糖皮质激素地塞米松（DEX）对 3 - 4 日龄幼鼠海马中脑源性神经营养因子（BDNF）的 mRNA 水平、细胞凋亡关键蛋白酶半胱天冬酶 - 3（caspase - 3）、表达活性 caspase - 3 的细胞数量，以及 proBDNF、matBDNF 和关键抗凋亡蛋白 BCL - x L 水平的影响 ...

Brain-derived neurotrophic factor (BDNF) has an important role in supporting neuronal survival, which has encouraged studies of its therapeutic potential for neurodegenerative disorders such as ...

People who carry excess fat around the stomach are prone to obesity-related health issues and a new a study suggests that having a so-called pot belly may also be a sign of brain aging.

Moreover, it has been reported that higher brain BDNF expression is associated with slower cognitive decline in older adults.

However, in aged mice, a deficiency of adipose 11β-HSD1 leads to insensitivity to steroid hormones, which in turn decreases the expression of adipose CX3CL1 and subsequently reduces brain BDNF ...

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease.

In young mice, the adipose-to-brain crosstalk helps sustain cognitive health by ensuring adequate BDNF production. However, ...