针对急性髓系白血病(AML)患者高肿瘤负荷导致过继性T细胞疗法(ACT)效果不佳的问题，研究人员开展BH3模拟物(如venetoclax)联合WT1 ...

It also shows that molecules known as BH3 mimetics can improve the effect ... in patients with non-small cell lung cancer who show molecular alterations in this oncogene. Currently, four ...

including the development of BH3 domain mimetics. Now, the authors describe obatoclax, a novel small-molecule inhibitor of BCL2 family pro-survival proteins. Of particular interest is its activity ...

In this group, 5% of patients show molecular alterations in the ALK gene ... of Barcelona reveals that the functional assay dynamic BH3 profiling (DBP) can predict whether this treatment will ...