生物通7 天
巨噬细胞外泌体中 BRCA1 对冠心病的影响及潜在治疗新靶点
他们聚焦于 BRCA1 基因在 M1 巨噬细胞来源的外泌体中的功能，以及其对心肌细胞凋亡和冠状动脉粥样硬化的影响。该研究成果发表在《Cell Biology and Toxicology》杂志上，为冠心病的治疗开辟了新的道路。 研究人员在研究过程中运用了多种关键技术方法。他们从公共 ...
Science Daily13 天
Scientists upends scientific understanding of how anticancer drugs kill cancer
BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...
News Medical25 天
Study challenges role of BRCA1 mutation in prostate cancer initiation
including cancer cells, to repair DNA damage, in men with BRCA1 genetic variants, say the researchers. A linked editorial suggests that the findings pave the way for greater refinement of genetic ...
Medical Xpress24 天
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
including cancer cells, to repair DNA damage, in men with BRCA1 genetic variants, say the researchers. A linked editorial suggests that the findings pave the way for greater refinement of genetic ...
Scientists Capture First-Ever Images of Cancer’s Covert DNA Repair Strategy
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
University of Birmingham16 天
Understanding why PARP inhibitors may stop working for some cancer patients
New findings could help identify patients likely to become resistant to anti-cancer drugs and aid exploring different ways to ...
Medical Xpress24 天
Research upends scientific understanding of how anticancer drugs work
Whalen, Ph.D., poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells. Their work, published in Nature Cancer, illustrates how a small DNA nick—a ...