Triple negative breast cancer accounts for 15% of cases but causes a disproportionate number of deaths. Learn about symptoms ...

The breast cancer susceptibility gene 1 (BRCA1) protein forms complexes with other protein components to regulate the cellular response to DNA damage. Three studies now report the identification ...

Women with a BRCA1 or BRCA2 mutation have up to a 72% chance of breast cancer during their lifetime. Normally, the PALB2 gene makes a protein that works with the BRCA2 gene protein to repair ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

Technically, Pol-theta is an enzyme—a type of protein that speeds up chemical ... but some cancers—particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ovarian ...

Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. Nature Cancer , 2025; 6 (2): 278 DOI: 10.1038/s43018-024-00902-1 Cite This ...

owing to dysfunction of the breast cancer type 1 susceptibility protein (BRCA1). Indeed, mutations in BRCA1 are known to predispose individuals to hereditary breast and ovarian cancers.

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

Breast cancer is the most commonly diagnosed cancer among women in the U.S. and is currently one of the leading causes of ...

Technically, Pol-theta is an enzyme -- a type of protein that speeds up chemical ... but some cancers -- particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ...