The breast cancer susceptibility gene 1 (BRCA1) protein forms complexes with other protein components to regulate the cellular response to DNA damage. Three studies now report the identification ...

owing to dysfunction of the breast cancer type 1 susceptibility protein (BRCA1). Indeed, mutations in BRCA1 are known to predispose individuals to hereditary breast and ovarian cancers.

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...

Technically, Pol-theta is an enzyme -- a type of protein that speeds up chemical ... but some cancers -- particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ...

Breast cancer is the most commonly diagnosed cancer among women in the U.S. and is currently one of the leading causes of ...