DNA repair protein's unexpected structure may lead to new cancer treatments
A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and ...
来自MSN4 个月
Research shows how even one faulty copy of the BRCA1 gene can fuel breast cancer
BRCA1 belongs to a family of tumor suppressor ... Specifically, these cells contained alterations in the structure and organization of chromatin, the material that helps package and maintain ...
Science Daily27 天
Scientists upends scientific understanding of how anticancer drugs kill cancer
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. Nature Cancer , 2025; 6 (2): 278 DOI: 10.1038/s43018-024-00902-1 Cite This ...
EurekAlert!27 天
Research by UMass Chan scientists upends scientific understanding of how anticancer drugs ...
Whalen, PhD, poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells. Published in Nature Cancer, their work illustrates how a small DNA nick—a break ...