Apoptosis occurs in a wide range of human ... The effector molecules, such as BCL-2 associated x protein (BAX) and BCL-2 antagonist killer 1 (BAK1), contain BH domains 1–3 and permeabilize ...

and change in the mRNA levels of BCL-2/Bax, PTEN, and CDK4 as a consequence of MYC downregulation. Moreover, the researchers analyzed the effects of miR-377 on apoptosis, proliferation ...

John Seymour, MBBS, FRACP, PhD, explains why BCL-2 was considered an undruggable target for so long and what led to the development of effective BCL-2 inhibitors.