Here, we review how the signalling functions of bile acids can be exploited in the development of drugs for obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis, as well as other ...

Bile acids were first described chemically in 1849 ... We think they, or the bacteria that make them, may make good drug candidates — the ‘bugs as drugs’ idea. You could engineer bacterial ...

Shares of Mirum Pharmaceuticals, Inc. (MIRM) were in the spotlight on Monday after the company announced that the U.S. Food and Drug Administration (FDA) has approved a new tablet formulation of its ...

we can move beyond total bile acid measurements to assess the effect of specific bile acid variants, which may reveal new therapeutic targets and ways to improve fetal health. 4 Maxim Seferovic: My ...

A new study reveals how a critical imbalance in bile acids — the substances made by the liver that help digest fats — can trigger liver diseases, including hepatocellular carcinoma (HCC), the most ...

The gut microbiome seems to have an extensive and sometimes powerful influence on human biology. In recent years, scientists have begun to reveal the complex interactions between gut microbes and bile ...

Blocking YAP's repressor activity—either by enhancing FXR function or promoting bile acid excretion—could stop this damaging cycle, according to researchers. In experimental models, activating ...

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by ...