so the team looked at human skeletal muscle—vital for energy homeostasis in humans. In both human muscle cells and mouse brown adipocytes, bile acids increased D2 activity and oxygen consumption ...

There are trillions of microbes in the gastrointestinal tract, and we are starting to learn more about the exact mechanisms ...

Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids ...

New research has highlighted the contribution of metabolic pathways and the gut–joint axis in osteoarthritis, pinpointing new ...

Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity. Cell , 2025; DOI: 10.1016/j.cell.2025.02.029 Cite This Page : ...