With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al. examined the effects of bile acids on energy expenditure in mice, and in cultured mouse and human ...

Targeting bile acid signaling pathways shows promise as a potential treatment approach for these diseases. However, further ...

Scientists seek advanced technologies to better understand these metabolites and their influence on health. Thomas Horvath: Bile acids are cholesterol-derived compounds essential for digesting lipids ...

This altered form, called bile acid-methylcysteamine (BA–MCY), inhibits FXR to promote bile production and help boost fat metabolism. "Our study reveals there is a dialogue occurring between the ...

The bile acid activates AMP-activated protein kinase. “The discovery of LCA as a metabolic mediator of calorie restriction, and its effects across biochemical, cellular, and organismal levels, is ...

They do all this by binding to a receptor called FXR, which acts like a traffic light, controlling cholesterol metabolism and bile acid production to avoid excess buildup." Here's where the ...

This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal ...

They found that those who lost protection also had generally higher levels of bile acids ... that further functional validation of these metabolic pathways in the context of allergic tolerance ...

A thorough examination of modern drugs that target particular receptors and metabolic pathways for glucose and fat metabolism is presented. Recent research has revealed innovative targets and ...