Julian Walters and colleagues now report that reduced feedback inhibition of hepatic bile acid synthesis in the ileum may contribute to the pathogenesis of BAM due to unregulated bile acid ...

Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

And beyond their anti-cancer properties, what physiological effects might these androgen receptor–blocking bile acids have in ...

Osteoarthritis (OA) is one of the most prevalent conditions affecting tens of millions of U.S. adults, traditionally ...

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

UDCA works by inhibiting hydrophobic bile acid synthesis, enhancing bicarbonate secretion, and reducing cholangiocyte apoptosis. Despite its effectiveness, about 30–40% of PBC patients show an ...

what physiological effects might these androgen receptor-blocking bile acids have in healthy individuals? The team is now focused on precisely controlling the synthesis and release of these ...