The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi-enzymatic bile-acid biosynthetic pathway. Bile acids play a crucial role in dietary lipid ...

Bile reflux is similar to acid reflux in which stomach acids seep from the stomach into the esophagus because of a dysfunctional muscle (the lower esophageal sphincter). Bile reflux often develops ...

“In this study we discovered that YAP promotes tumor formation with a surprising role in regulating bile acid metabolism. Instead of encouraging cell growth as expected, YAP acts as a repressor, ...

"In this study we discovered that YAP promotes tumor formation with a surprising role in regulating bile acid metabolism. Instead of encouraging cell growth as expected, YAP acts as a repressor ...