3-methyladenine (3-MA) and wortmannin (Wm) also inhibit class I phosphatidylinositol 3-kinases (PI3K), but the overall effect of these compounds is a block in autophagy (because they inhibit the ...

The drug is known to block autophagy, a process that essentially acts as a cell's clean-up crew. Autophagy literally means ...

"This paper focuses on the theme of how autophagy-dependent secretion regulates autophagy itself," said Li Qilong, first author of the review. "We systematically explore the homeostatic ...

in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks. This vital process prevents the formation of ...

Researchers in Cambridge have identified a key enzyme that drives Parkinson’s disease and have shown that blocking it ...

Josephine Thinwa shares her journey to becoming a physician scientist and how this led her to investigate the role of a neurologically important kinase in virus-induced autophagy. Just like people ...

But autophagy does not work properly in Parkinson ... zebrafish and mouse models of Parkinson’s. By using drugs to block the function of ACLY, researchers were able to reduce the toxicity ...