These astonishing results indicate that DNA that was completely broken down can revert back ... et al. Double-strand breaks associated with repetitive DNA can reshape the genome.

The NTase domain binds to the broken DNA strands at and flanking the nick, the OB domain contacts the continuous template strand surrounding the nick, and the HhH domain binds both strands across the ...

BCDX2 attached to a broken DNA strand and promoted the formation of filaments composed of another protein, RAD51, that are essential for the repair to proceed 1. Cells have access to a variety of ...

"How cells prevent separation of broken DNA ends has been somewhat of ... "Individual PARP1 molecules detect the ...

One important player is the "molecular matchmaker" RAD51, which attaches itself to broken DNA strands and helps them find their way to their sibling strand, which then serves as a template to ...

APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...

Could viral infections play a role in Huntington's disease? Research suggests Apolipoprotein B mRNA editing catalytic ...

These tails are substrates for strand-exchange proteins that catalyze invasion of homologous duplexes ... The enzyme is a target of potent anti-cancer drugs such as etoposide, which trap the protein ...