胰腺癌（PDAC）预后差，现有治疗手段有限且缺乏有效预测生物标志物。研究人员整合单细胞（scRNA-seq）和 bulk RNA 测序数据，构建 DNA 损伤反应（DDR）相关预后模型。结果显示该模型能有效预测 PDAC 预后、免疫特征和治疗反应，为 PDAC 治疗提供新方向。 胰腺癌 ...

Traditional organoid culture can present challenges for the downstream analysis of single ... there are many genomic deviations that need to be detected and analyzed to further our understanding of ...