In addition, the association of CD3 with the TCR–peptide–MHC complex transmits the activation signal to intracellular signalling molecules to initiate a signalling cascade in the T cell.

An initial clue came from our efforts to see if loss of the TCR and CD3 chains from our Jurkat ... associated tyrosine kinase that could explain signaling. David Straus focused on one of the ...

Multiple studies have now demonstrated that 4-1BBL can independently provide co-stimulatory signals to induce T cell proliferation, separate from CD28 molecule signaling. Our other products for T cell ...