CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...

Method reveals unexpected behavior in molecular crowding during cell state transitions and suggests density as a biomarker for functional precision medicine.

What if we could reprogramme the TME itself? Cutting-edge research suggests that engineered mesenchymal stem cells (MSCs) ...

Spatial transcriptomics may transform prostate cancer research by mapping immune cell localization and gene expression in ...

Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths, and early detection is key to improving ...

Despite the massive successes of immunotherapy, which utilizes the body's immune system as a tool to fight cancer, therapy resistance is still a common treatment obstacle for many patients with solid ...

Autoimmune destruction of pancreatic β cells results in type 1 diabetes (T1D), with pancreatic immune infiltrate representing a key feature in this process. However, characterization of the ...

More information: Aleksej Frolov et al, Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15, Journal of Experimental Medicine (2025). DOI ...