The irreversibility of cell-cycle transitions is commonly thought ... which phosphorylates and inactivates Rb, and the ball is Cdk2–CycA,E, which can take over from CycD-dependent kinase ...

A n enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic resistance to common breast cancer drugs—including a class of targeted ...

By maintaining prolonged inhibition of the CDK2 pathway, the therapy may deliver more consistent and effective outcomes ...