A n enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic resistance to common breast cancer drugs—including a class of targeted ...

The irreversibility of cell-cycle transitions is commonly thought ... which phosphorylates and inactivates Rb, and the ball is Cdk2–CycA,E, which can take over from CycD-dependent kinase ...

Detailed biophysical and computational studies on one such interaction reveal a marvelously intricate, temporally regulated, multistep conduit for signal transduction in the cell cycle.