Cyclin E/Cdk2 seems to play at least three roles in driving Xic1 degradation. First, cyclin E/Cdk2 forms a ternary complex with Xic1, and formation of this complex seems necessary for the ...

WILMINGTON, DE — NiKang Therapeutics® Inc. has achieved a pivotal step in the development of its first-in-class CDK2 degrader ...

Genentech Inc. has disclosed molecular glue compounds with the ability to induce cyclin-dependent kinase 2 (CDK2)/protein cereblon (CRBN) interaction for CDK2 degradation reported to be useful for the ...

An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic resistance to common breast cancer drugs—including a class of targeted ...

L.-H. Tsai, E. Harlow, M. Meyerson, "Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase," Nature, 353:174-7, 1991. Li-Huei Tsai (Massachusetts General ...

This analysis segregated cell lines into distinct clusters demonstrating specific dependencies on various cyclin and CDK genes, revealing tumor types that are exceptionally dependent on CDK2 and more ...