A n enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic resistance to common breast cancer drugs—including a class of targeted ...

(C) According to the classical model of cell cycle control, D-type cyclins and CDK4 or CDK6 regulate events in early G1 phase (not shown), cyclin E-CDK2 triggers S phase, cyclin A-CDK2 and cyclin ...

The irreversibility of cell-cycle transitions is commonly thought ... which phosphorylates and inactivates Rb, and the ball is Cdk2–CycA,E, which can take over from CycD-dependent kinase ...