根据发表在《自然-癌症》杂志上的一项新研究，一种长期以来被认为是导致食管癌发展的基因缺陷，实际上可能在疾病早期发挥保护作用。这一意想不到的发现可以帮助医生确定哪些人患癌症的风险更大，从而有可能制定出更个性化、更有效的预防策略。

Scientists from the Barts Cancer Institute and the Francis Crick Institute have demonstrated that a genetic flaw that has long been thought to cause esophageal cancer may actually protect against the ...

In the p53 pathway, signals such as DNA damage induce the ARF (also known as p14 in humans and p19 in mice) product of the CDKN2A locus. ARF increases p53 levels by sequestering MDM2, which ...

Loss of p53 strongly drives the progression of disease from Barrett's to cancer. The team found that potentially cancerous cells that lost both CDKN2A and p53 were weakened and unable to compete ...

Loss of p53 strongly drives the progression of disease from Barrett's to cancer. The team found that potentially cancerous cells that lost both CDKN2A and p53 were weakened and unable to compete ...

Loss of p53 strongly drives the progression of disease from Barrett’s to cancer. The team found that potentially cancerous cells that lost both CDKN2A and p53 were weakened and unable to compete ...