与之相对的 CRISPRi（CRISPR interference），则是基因表达的 “抑制剂”。它能够阻止转录过程的进行，使特定基因的表达受到抑制，就像给基因的表达按下了 “暂停键”，有助于深入探究基因在生物过程中的作用机制。 prime editing（引导编辑）更是技术革新的代表 ...

Researchers have long wondered why some people with high-risk Parkinson’s gene variants develop the disease while others ...

A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also ...

Parkinson's disease is the second most common neurodegenerative disease in the world... | Genetics And Genomics ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

US researchers have used modern technology CRISPR interference to identify a new set of genes that contribute to the risk of ...

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...

A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that ...

A study led by Northwestern Medicine used CRISPR interference to identify Commander proteins involved in Parkinson’s disease ...

CRISPR technology uncovers new key genes and pathways linked to Parkinson’s disease, offering insights into risk and ...