The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

We reasoned that using antibodies with a long half-life and specificity would help elucidate the relationship between CXCL12/CXCR4 signaling and the liver cancer microenvironment, reduce off ...

Both approaches led to fewer granulomas forming compared to controls. "We found that CXCR4 signaling is crucial to the development of tissue granulomas, and blocking that signal can inhibit ...