For instance, calcium overload in mitochondria can lead to the opening of the mitochondrial permeability transition pore (mPTP), which triggers cell death through apoptotic or necrotic pathways.

Consistent with our conclusion that blockade of calcium uptake into the mitochondria is neuroprotective, the onset of neuronal cell death is delayed by inclusion of rotenone and oligomycin in an ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function.

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...