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CAMK2A 基因变异致智力障碍的机制揭秘:从分子到行为的探索
智力障碍(ID)等神经发育障碍(NDDs)发病机制不明,名古屋大学等机构研究人员构建携带 CAMK2A 基因 P212L 变异的敲入小鼠模型开展研究。结果显示,该变异会增强 CaMKIIα 信号,导致学习障碍等 ID/NDDs 特征。这为相关疾病研究和治疗提供新方向。 在神秘的大脑 ...
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