At least four DPYD variants in Europeans are widely recognized in fluorouracil and capecitabine FDA prescribing labels for their association with severe toxicity. Recent work has identified other ...

In the past 5–10 years there has been a growing trend for substituting conventional 5-fluorouracil with the oral prodrug of 5-fluorouracil, capecitabine, in chemotherapy regimens. This regimen ...

Approximately 924,000 prescriptions were written for fluorouracil and capecitabine in 2022 ... patients carry two copies of a variant in the DPYD gene, resulting in the absence of the DPD enzyme.

Background. A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin.

Market research from the manufacturers of capecitabine indicates that the clinical community has voted with its empirical feet—it is relatively rare for US-based oncologists to prescribe the ...