据介绍，通过纳米流式分析、蛋白组学测序和透射电镜等多项技术，研究团队发现MI后CFs来源的小细胞外囊泡富含损伤线粒体成分（CFs-mt-sEVs）。细胞因子检测、流式细胞术、免疫荧光染色和Seahorse分析等结果显示，CFs-mt-sEVs将损伤的线粒体成分转移至巨噬细胞，影响其代谢水平和炎症状态。

A unique subset of cardiac fibroblasts expressing CD248 orchestrates immune–fibroblast crosstalk, promoting chronic cardiac fibrosis and dysfunction after ischemia–reperfusion injury ...

Inflammatory arthritis encompasses a group of autoimmune diseases, including rheumatoid arthritis (RA), psoriatic arthritis ...

In addition, we study the paracrine signaling interactions between cardiac fibroblasts and myocytes, and their role in profibrotic signaling. New therapies in development include small molecule ...