An Israeli study has identified TRIM63 as a significant genetic contributor to hypertrophic cardiomyopathy (HCM)—the most ...

In DCM, the heart’s chambers enlarge ... appropriate myosin heavy chain protein shape and aid its incorporation into the sarcomere, as well as how mutations in the gene for this protein may disrupt ...

Illustration of the interacting thick and thin filaments in the cardiac sarcomere based on structural cryo electron-tomography data. Credit MPI of Molecular Physiology ...

The novel cardiac myosin inhibitor aficamten improved ... blocker use and independent of the presence of a pathogenic sarcomere gene variant," the researchers noted. Among the secondary endpoints ...

In the cardiovascular system, AS of transcripts of sarcomere, ion channel, and cell signaling protein genes, as well as long ... In addition, multiple hereditary heart-related diseases are caused ...

and an increased risk of sudden cardiac death. It is caused by mutations in sarcomere protein genes, leading to altered cell metabolism, including oxidative stress and mitochondrial dysfunction.